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June 2025

2025 American College of Rheumatology (ACR) Guideline for the Treatment of Systemic Lupus Erythematosus (SLE) Guideline Summary

https://rheumatology.org/lupus-guideline#2025-sle-guideline

The ACR have published their summary of the 2025 Systemic Lupus Erythematosus Guideline. This updated lupus guideline project is divided into two manuscripts that include renal published (link) and non renal recommendations that are available online in summary now, and the manuscript format due to follow in late 2025.

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September 2024

CD19-CAR T-cell therapy induces deep tissue depletion of B cells

Ann Rheum Dis 2024;0:1–8 DOI 10.1136/ard-2024-226142

Tur et al. demonstrated that CD19-targeting CAR T-cell therapy results in the depletion of B cells within deep tissues. The study highlights significant reductions in pathogenic B-cell populations, particularly in autoimmune diseases, after CD19-CAR T-cell administration.

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February 2023