Smith-specific regulatory T cells halt the progression of lupus nephritis
Nat Commun. 2024 Feb 6;15(1):899 DOI: 10.1038/s41467-024-45056-x
Compared with polyclonal mock-transduced regulatory T cells (Tregs), Smith(Sm)-Tregs potently suppress Sm-specific pro-inflammatory responses in vitro and suppress disease progression in a humanised mouse model of lupus nephritis.
This study by Eggenhuizen, et al. details the pipeline for the development of antigen-specific Tregs for autoimmune disease. All Sm peptides were tested for binding affinity to HLA-DR15 prior to murine testing.
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