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Find coverage of the latest original articles on Lupus, focusing on those with data on therapeutic interventions and those that have clinical impact.

This activity is supported by an educational grant from AstraZeneca.

Smith-specific regulatory T cells halt the progression of lupus nephritis

Nat Commun. 2024 Feb 6;15(1):899 DOI: 10.1038/s41467-024-45056-x

Compared with polyclonal mock-transduced regulatory T cells (Tregs), Smith(Sm)-Tregs potently suppress Sm-specific pro-inflammatory responses in vitro and suppress disease progression in a humanised mouse model of lupus nephritis.

This study by Eggenhuizen, et al. details the pipeline for the development of antigen-specific Tregs for autoimmune disease. All Sm peptides were tested for binding affinity to HLA-DR15 prior to murine testing.

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