Urinary soluble CD163 is useful as "liquid biopsy" marker in lupus nephritis at both diagnosis and follow-up to predict impending flares
J Transl Autoimmun 2024;9:100244 DOI 10.1016/j.jtauto.2024.100244
Renaudineau, et al. show that the urinary sCD163/creatinurea ratio is a parameter than can be used in addition to anti-dsDNA antibodies, anti-C1q antibodies, C3 complement fraction, the protein excretion to creatinine ratio and the estimated glomerular filtration rate.
237 SLE patients were retrospectively selected to test the added value to explore the urinary sCD163 factor as a “liquid kidney biopsy” biomarker in a large panel of serological and urinary LN/SLE biomarkers. These biomarkers were tested for their capacity to discriminate against active LN, and for their performance to explore active/chronic disease variations during follow-up.
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