Predictors of damage accrual by organ domain in systemic lupus erythematosus
Rheumatology 2025;18:keaf610 Doi: 10.1093/rheumatology/keaf610 Epub ahead of print
Kandane-Rathnayake et al. reported that risk factors for individual organ system damage were highly varied in patients with SLE, and not all factors associated with domain-specific damage were captured by summed systemic lupus international collaborating clinics/american college of rheumatology damage index (SLICC/ACR SDI) for overall organ damage.
In examining predictors of both overall and domain-specific organ damage, the authors found that several factors associated with domain-specific damage were not captured when analysing overall damage scores, predictors of overall damage were consistent with known risk factors and previous studies, and domain-specific disease activity and organ damage often predicted further damage both within and across domains.
