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November 2025

Low-dose belimumab reduced risk of flares in patients with systemic lupus erythematosus: A multicentre, randomised, double-blind, placebo-controlled trial

Ann Rheum Dis 2025 Doi: 10.1016/j.ard.2025.10.010. Epub ahead of print

Sun et al. provides the first RCT evidence that low-dose belimumab reduces flares in patients with SLE with low-grade disease activity. Authors evaluated the efficacy of low-dose belimumab for disease flare  prevention in Chinese patients with low-grade SLE (SELENA-SLEDAI ≤6).

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