Health Related Quality of Life, Remission and Low Lupus Disease Activity State in Patients with Systemic Lupus Erythematosus

Rheumatology (Oxford). 2023 doi: 10.1093/rheumatology/kead407 Epub ahead of print

One of the first studies to investigate associations between disease activity and QoL, using validated generic and disease-specific PRO questionnaires, found that DORIS remission and LLDAS were associated with significant and clinically relevant higher QoL in most PRO domains of the LupusPRO (disease specific) and SF-36 (generic) questionnaires, but not with LupusQoL and SLEQOL disease-specific questionnaires.

A link between remission and improved HRQoL has not been clearly established for SLE. Disease-specific PROs include additional domains associated with SLE and may show such a link, but current data are scarce.

To help address this, Thibault, et al. measured cross-sectional differences in generic and specific HRQoL scores between SLE patients who did or did not achieve remission