Association of sustained lupus low disease activity state with improved outcomes in systemic lupus erythematosus: a multinational prospective cohort study
Lancet Rheumatol 2024:S2665-9913(24)00121-8 DOI 10.1016/S2665-9913(24)00121-8 Epub ahead of print
This study by Golder, et al. showed a significant protective association of lupus low disease activity state (LLDAS) and remission against damage accrual and flare. The authors also found a threshold of 3 months sustained LLDAS or remission, and that 3 months of sustained LLDAS are attainable in the setting of a 6–12-month clinical trial.
Patients with SLE from 25 centres in 12 countries were followed up from 1 May 2013 to 31 December 2020 in a prospective, multinational, longitudinal cohort study. The association of increasing time spent in LLDAS or remission with disease outcomes was assessed at each visit.
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