Association of lupus low disease activity state and remission with reduced organ damage and flare in systemic lupus erythematosus patients with high disease activity
Rheumatology 2024; Epub ahead of print DOI: 10.1093/rheumatology/keae631
Kandane-Rathnayake et al. demonstrated that achieving Lupus Low Disease Activity State (LLDAS) or remission in patients with high disease activity status (HDAS) significantly reduces the risk of organ damage accrual and flares. However, HDAS was found to be a poor prognostic indicator as fewer patients with HDAS attained and sustained LLDAS or remission when compared with non-HDAS patients.
The study was a multi-national longitudinal cohort analysis that involved 1,029 HDAS SLE patients, using data from 2013 to 2020. The study assessed the frequency and impact of LLDAS and remission attainment in HDAS patients on outcomes like organ damage and disease flare.
Keywords:
