Effect of long-term voclosporin treatment on renal histology in patients with active lupus nephritis with repeat renal biopsies
Arthritis & Rheumatology 2025; 0:1–7 doi: 10.1002/art.43209
Exposure to voclosporin for a median of 18 months was not associated with onset or progression of nephrotoxicity based on evaluation of histologic compartments and vascular lesions. Rovin et al. characterised the impact of voclosporin on kidney histology in patients with LN who had protocolized repeat kidney biopsies in the AURORA clinical trials.
Rovin et al. was the first study to assess histologic changes in the kidneys of patients with active LN enrolled in a randomised, blinded clinical trial and treated with voclosporin or placebo in combination with mycophenolate mofetil and low-dose GCs.