Remission of Lupus Nephritis: The Trajectory of Histological Response in Successfully Treated Patients
Lupus Sci Med. 2023;10(1):e000932 doi: 10.1136/lupus-2023-000932
LN histological activity takes months to years to resolve, providing a rationale for the need of long-term, well-tolerated maintenance immunosuppression.
The time course of kidney repair during active immunosuppressive treatment of lupus nephritis has not previously been characterised. To this end, Malvar, et al. studied patients with proliferative ± membranous LN, to investigate changes in kidney histology over time in patients with LN undergoing immunosuppressive treatment. The study describes, for the first time, how kidneys with LN heal at the tissue level.
