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Showing 2 results for “Buyon JP”.

May 2023

High Systemic Type I Interferon Activity Is Associated with Active Class III/IV Lupus Nephritis

The Journal of Rheumatology 2022; 49:388–97 DOI 10.3899/jrheum.210391

Iwamoto, et al. aimed to determine the association of serum IFN activity with subtypes of lupus nephritis. This study suggests that systemic high type I IFN in SLE is involved in the pathogenesis of severe class III/IV LN and contributes to severe kidney involvement in European-American patients with SLE. However, this effect was independent of anti‑dsDNA antibody status and complement levels. Expression of type I IFN was not found to be clearly related to plasmacytoid dendritic cell infiltration, although it did directly stimulate podocytes to induce chemokines and molecules related to podocyte injury.