Publications
Find coverage of the latest original articles on Lupus, focusing on those with data on therapeutic interventions and those that have clinical impact.
October 2024
Attainment of EULAR/ERA-EDTA targets of therapy with current immunosuppressive regimens and adjustments in treatment: a multicentre, real-life observational study
RMD Open 2024;10:e004437 DOI: 10.1136/rmdopen-2024-004437
Pappa et al. explored the achievement of EULAR/ERA-EDTA targets in lupus nephritis patients receiving standard immunosuppressive therapy. Two-thirds of the cohort achieved target responses by 12 months, but 20% required therapy modifications due to suboptimal outcomes.
April 2024
CD19 CAR T-Cell therapy in autoimmune disease - A case series with follow-up
N Engl J Med 2024;390(8):687–700 DOI 10.1056/NEJMoa2308917
In this case series by Müller, et al., eight patients who received a CD19 CAR T-cell infusion achieved Definition of Remission in SLE (DORIS) remission, Lupus Low Disease Activity State and a SLEDAI 2K score of 0 at 6 months post-infusion. Long-term follow-up through 24 months showed that SLE disease activity remained absent
in all eight patients.