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Showing 5 results for “flares” published 2024.

August 2024

Urinary soluble CD163 is useful as "liquid biopsy" marker in lupus nephritis at both diagnosis and follow-up to predict impending flares

J Transl Autoimmun 2024;9:100244 DOI 10.1016/j.jtauto.2024.100244

Renaudineau, et al. show that the urinary sCD163/creatinurea ratio is a parameter than can be used in addition to anti-dsDNA antibodies, anti-C1q antibodies, C3 complement fraction, the protein excretion to creatinine ratio and the estimated glomerular filtration rate.

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Immunosuppressives discontinuation after renal response in lupus nephritis: predictors of flares, time to withdrawal and long-term outcomes

Rheumatol 2024 DOI 10.1093/rheumatology/keae381 Epub ahead of print

This study by Panagiotopoulos, et al. showed that an early complete renal response achievement, persistent hydroxychloroquine use, and the maintenance of optimal low disease activity during follow-up in immunosuppressive (IS) tapering and discontinuation are fundamental in LN treatment. The authors also found that long-term renal outcomes are mainly associated with renal flares during IS tapering.

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July 2024

Efficacy and safety of upadacitinib or elsubrutinib alone or in combination for systemic lupus erythematosus: A Phase 2 randomized controlled trial

Arthritis Rheumatol 2024 DOI: 10.1002/art.42926 Epub ahead of print

Daily oral upadacitinib 30 mg and ABBV-599 high dose (elsubrutinib 60 mg QD + upadacitinib 30 mg) were effective in multiple outcome measures including disease activity, flares, time to first flare, and joint counts.

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March 2024
February 2024

Predictors of Renal Flares in Systemic Lupus Erythematosus: A Post-hoc Analysis of Four Phase III Clinical Trials of Belimumab

Rheumatology (Oxford) 2024 DOI: 10.1093/rheumatology/keae023 Epub ahead of print

High baseline proteinuria levels, hypoalbuminaemia, and C3 consumption were associated with
renal flare development. Renal flares remain common in patients with SLE, however causative factors are still largely unknown. Jagerback, et al. conducted a post-hoc analysis of pooled BLISS trial data to identify predictors of renal flares.

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