Publications
Find coverage of the latest original articles on Lupus, focusing on those with data on therapeutic interventions and those that have clinical impact.
December 2025
Predictors of damage accrual by organ domain in systemic lupus erythematosus
Rheumatology 2025;18:keaf610 Doi: 10.1093/rheumatology/keaf610 Epub ahead of print
Kandane-Rathnayake et al. reported that risk factors for individual organ system damage were highly varied in patients with SLE, and not all factors associated with domain-specific damage were captured by summed systemic lupus international collaborating clinics/american college of rheumatology damage index (SLICC/ACR SDI) for overall organ damage.
September 2025
Efficacy and safety of upadacitinib as monotherapy or combined with elsubrutinib for the treatment of systemic lupus erythematosus: results through 104 weeks in a long-term extension study
RMD Open 2025;11:e005742 Doi:10.1136/rmdopen-2025-005742
In this long-term extension of the Phase 2 SLEek study, Merrill et al. report that through an additional 56-weeks of treatment, upadacitinib as monotherapy or combined with elsubrutinib demonstrated sustained or improved efficacy in multiple endpoints in patients with moderately to severely active SLE.