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Showing 2 results for “T-cell”.

September 2024

CD19-CAR T-cell therapy induces deep tissue depletion of B cells

Ann Rheum Dis 2024;0:1–8 DOI 10.1136/ard-2024-226142

Tur et al. demonstrated that CD19-targeting CAR T-cell therapy results in the depletion of B cells within deep tissues. The study highlights significant reductions in pathogenic B-cell populations, particularly in autoimmune diseases, after CD19-CAR T-cell administration.

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April 2024

CD19 CAR T-Cell therapy in autoimmune disease - A case series with follow-up

N Engl J Med 2024;390(8):687–700 DOI 10.1056/NEJMoa2308917

In this case series by Müller, et al., eight patients who received a CD19 CAR T-cell infusion achieved Definition of Remission in SLE (DORIS) remission, Lupus Low Disease Activity State and a SLEDAI 2K score of 0 at 6 months post-infusion. Long-term follow-up through 24 months showed that SLE disease activity remained absent
in all eight patients.

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